这种“原则性与灵活性相结合”的监管思路，为不同严重程度、不同疾病类型的自免CAR-T开发提供了路径指引。在外界看来，这等于间接回答了自免CAR-T II期临床优异的表现能不能直接上市的问题。答案是肯定的，但需要做跟踪反馈。
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The law under consideration “delinks” PBM compensation from manufacturer rebates in Medicare and requires flat administrative fees, certified at fair market value. It also mandates that rebates be passed through to health plan sponsors in the employer-sponsored market. This sounds appealing, but incentives matter. When compensation no longer depends on securing better terms, bargaining effort becomes a cost center rather than a profit center. PBMs will still compete for contracts, but competition on administrative fees isn’t the same as competition on aggressive price concessions and won’t lower drug prices.